Antiulcer activity of euphorbia hirta against experimentally induced ulcer in rats rathnakumar. Herbal plants are considered as safe for peptic ulcer treatment with less side effect. Exploring indian medicinal plants for antiulcer activity. It is one of the sacred herbs for hindus in the indian subcontinent. A large number of populations are now relying on these medicinal plants as they are relatively safe, cheap and have no adverse effects.
Exploring indian medicinal plants for antiulcer activityexploring indian medicinal plants for antiulcer activity we read with interest the article exploring indian medicinal plants for anti ulcer activity indian j pharmacol 2006. Peptic ulcer, proton pump inhibitors, medicinal plants, poly. An aphrodisiac is defined as an agent that arouses sexual desire. Ulcers are induced by aspirin plus pylorus ligated gastric ulceration in rats and aqueous extract of leaves is to be administered orally for 21 days, daily dose of 1 gmkg. India is a well known country for various types of medicinal plants and leading in spices and medicinal plants in the world5.
Antioxidant properties of several medicinal plants growing. Indian medicinal plants, peptic ulcer, ocimum sanctum. Gautam palit division of pharmacology, central drug research institute, lucknow 226 001 india. Antiulcer activity of some selected medicinal plants. Hence, it establishes the fact that the methanol extract of antiulcer activity of acacia farnesiana l. It may typically in the stomach gastric ulcer or first few centimeters. Peptic ulcer, gastric ulcer, aggressive factors, defensive factors, abdominal pain, medicinal plants.
Synthetic hepatotoxic chemicals generally damage liver by inducing lipid peroxidation and other oxidative free radical 23. The mechanism involved in production of antiulcer activity by plant. Currently medicinal plants have become the paramount source of drug discovery in research for treating diverse form of diseases including cancer. Plants of the american continent with antiulcer activity. Journal of ethnopharmacology 90 2004 205215 antioxidant, antimicrobial, antiulcer and analgesic activities of nettle urtica dioica l. Antioxidant, antimicrobial, antiulcer and analgesic. Andrographis paniculata ap is an important medicinal herb generally called the king of bitters. Antiulcer activity of muntingia calabura leaves involves.
Gsei with low flavanol content, gseii with high flavanol content, and procyanidins at a dose of 200 mgkg strongly inhibited the stomach mucosal injury. Axid nitzatidine diarrhea, headache, nausea and vomiting, sore throat. Pdf for centuries, many kinds of native plants and their products have been used for the treatment of gastric ulcers by traditional healers in phayao. In case of the rest of the medicinal plants the 2008, serotonin and egg. Various plants like abutilon indicum, ageratum, allophylus serratus, aloe barbadensis. Antiinflammatory and antioxidant activities of medicinal. Antiulcer activity of morinda citrifolia linn fruit extract. Evaluation of antiulcer activity of the leaf extract of osyris. Anthelmintic activity of extracts of some medicinal plants 185 of approximately equal sized indian earthworms consisting of six earthworms in each group were released into 50 ml of. The current study aimed to investigate the polyphenol content in some of these medicinal plants and to point out the relationship between their antioxidant capacity and antiinflammatory activities. Evaluation of antiulcer activity of the terpenoid fraction from the leaves of thespesia populnea l malvaceae in albino rats.
Although extensive research has been conducted in this area, recent studies with significant findings involving cynodon dactylon, ocimum sanctum, glycyrrhiza glabra, ficus religiosa,are emphasized here. We had studied at the medical college, trivandrum, properties of nimbidine, the bitter amorphous. Despite the claims regarding the medicinal uses of m. The formation of peptic ulcers depends on the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defenses. Exploring indian medicinal plants for antiulcer activity p. One of the most active isolated compounds forms ap andrographolide, a bicyclic diterpenoid lactone. Antifungal activity, phytochemical analysis of solanum nigrum l. To study the antiulcer activity of aqueous extract of roots of tephrosia purpurea aetp using different models of gastric and duodenal ulceration in rats.
Acidic heteroxylans from medicinal plants and their antiulcer activity. Mullick road, kolkat a 700 032, india 2deptartment of biochemistry, central drug research. A number of drugs including proton pump inhibitors and h 2. Qualea grandiflora, a brazilian cerrado medicinal plant. May, 2017 1644 ocimum sanctum lamiaceae is commonly known as holy basil. Pdf antiinflammatory and antioxidant activities of. Antiulcer activity of aetp was studied in rats in which gastric ulcers were induced by oral administration of ethanol or 0.
Therefore, efforts should be directed towards isolation and characterization of the active principles and elucidation of the relationship between structure and activity. Full text evaluation of antiulcer activity of the leaf extract of osyris. S4 1department of ophthalmology,sri lakshminarayana institute of medical sciences, pondicherry, india 2department of pharmacology, dreamz college of pharmacy, khilra, sundernagar, himachal pradesh. In spite of being one of the wellknown medicinal plants used inindian traditional medicine to treat several ailments, studies pertaining to the pharmacologicalproperties of some medicinal plants are very scarce. Exploring indian medicinal plants for antiulcer activity bioline. Peptic ulcer, medicinal plants, antiulcer activity. Banerjee 1, 1department of physiology, indian institute of chemical biology, 4, raja s. Witch hazel, propolis epid, artichoke, and hawthorn afforded. The in vivo bioassay was conducted on formalin mosaddek et al. A potential of some medicinal plants as an antiulcer.
The leaves of dica were washed thoroughly in water to remove foreign matter and allowed to shade dry with a relative humidity of 4045%. The antiulcer activity of a hydroethanolic e xtract prepared from the stems of kielmeyera coriacea mart. There are various medicinal plants and their extracts containing active chemical constituents, e. Some medicinal plants have great pharmaceutical value and have been traditionally used as home based remedies6. Evaluation of phytochemical and antiulcer activity of coriandrum sativum l. Patil ph, patil jy, mahale jn, patel jb, surana sj. Definition antiulcer drugs are a class of drugs, exclusive of the antibacterial agents, used to treat ulcers in the stomach and the upper part of the small intestine.
Anthelmintic activity of extracts of some medicinal plants. Antiulcer drugs brand name generic name possible common side effects include. For centuries, many kinds of native plants and their products have been used for the treatment of gastric ulcers by traditional healers in phayao province. Biological actions and medicinal applic ations ishita chattopadhyay 1, kaushik biswas 1, uday bandyo p adhyay 2 and ranajit k. Medicinal plants provide an effective and safer way in disease management. Aroma is offering an ineffable support to the folk medicine, which is a traditional medicine for the treatment of ulcers in india. Pdf a peptic ulcer is erosion in a segment of the gastro intestinal mucosa.
Asteraceae, fabaceae, celastraceae and turneraceae, with, 6, 3 and 2 species, respectively, studied to date. Commonly used medicinal plant extracts with standardized content of polyphenols were investigated for their total antioxidant activity taa. This paper outlines the properties of some medicinal plants that exhibit antiulcer activity. Antiulcer activity of grape seed extract and procyanidins. We conclude that plant extracts are potential sources of new antiulcer agents. Antiulcer drugs definition of antiulcer drugs by medical. Then, the leaves were powdered in roller grinder and passed through a sieve no. Guttiferae was evaluated in rats employing the e thanolacid, acute stress and. Various plants like excoecaria agallocha, mentha arvensis, utleria salicifolia, emblica officinalis etc. Plants as natural antiinflammatory agents unlike modern allopathic drugs which are single active components that target one specific pathway. As herbal medicines are considered as safe for the treatment of ulcers with lesser adverse effects, economical, effective, relatively less toxic, extensive research is carried out in search for potent antiulcer agents of plant origin. It was possible to list 58 species of medicinal plants studied, which showed antiulcer activity. The fixed oil significantly possessed antiulcer activity due to its. Since a wide range of secondary metabolites occur in medicinal plants with antiulcer activity lewis and hanson, 1991, we also investigated the phytochemical profile of the he of qualea grandiflora as well as its acute toxicity.
Exploring indian medicinal plants for antiulcer activity p dharmani, gautam palit division of pharmacology, central drug research institute, lucknow 226 001, india. Adansonia digitata linn it is commonly known as aobab, rahmamlika. Those species are distributed in 37 families, of which the following stood out. To assess the antiulcer activity of varied concentrations of the ebl 200 and 400 mgkg orally was evaluated for ethanol induced ulcer in mice and pylorus ligation induced ulcer in rats. Antiulcer activity of ethanolic extract of salvadora.
Introduction increasing role of the who monographs on selected medicinal plants over the past two decades, there has been a tremendous increase in the use of herbal medicine. Antiulcer activities of grape seed extracts gsei and gseii and procyanidins were investigated using rats. Antifungal activity, phytochemical analysis of solanum. Green tea, oligomeric procyanidins from grape seed and pine bark, bilberry, and ginkgo exhibited taa in the range of 5.
We studied the antiulcer activity and acute toxicity of some medicinal plants. Pdf antiulcer activity of some selected medicinal plants. Total alkaloids, tannin content, and antiulcer assay of. Many medicinal plants exhibit antiulcer activity and found useful in the treatment of peptic ulcer. Therefore, this study aimed to investigate the antiulcer effect of memc using different ulcerogenic models. It is known that procyanidins, which are contained in grape seeds, are antioxidative and have certain biological effects.